fentanyl transdermal and diazepam equally boost sedation. Avoid or Use Alternate Drug. Restrict use to people for whom alternate procedure selections are insufficient
sage decreases effects of diazepam by pharmacodynamic antagonism. Slight/Significance Unidentified. Theoretical interaction; some species of sage might result in convulsions.
diazepam will raise the amount or outcome of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
lasmiditan, diazepam. Both boosts effects of one other by sedation. Use Caution/Monitor. Coadministration of lasmiditan along with other CNS depressant medication, which includes Alcoholic beverages have not been evaluated in scientific research. Lasmiditan may perhaps cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
efavirenz will decrease the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
If any withdrawal response develops, look at pausing taper or raising dose to former tapered dosage degree; subsequently minimize dose more slowly but surely
Suggest equally individuals and caregivers regarding the challenges of respiratory depression and sedation when Valium is employed with opioids. Recommend individuals not to generate or run hefty equipment till the consequences of concomitant use While using the opioid are already determined (see Safety measures: Drug Interactions).
Concomitant use of benzodiazepines and opioids may well cause profound sedation, respiratory depression, coma, and Demise
Observe for signs of urinary retention or lessened gastric motility if oliceridine is coadministered with anticholinergics.
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will increase the degree or impact of diazepam by lowering metabolism.
Data that may help you have an understanding of the read more probable harms from lengthy-expression usage of benzodiazepines and the way to lower possibility of dependence.
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If this drug is employed for the duration of pregnancy, or if the individual gets to be pregnant though getting this drug, the affected person must be apprised with the likely hazard towards the fetus 15. Individuals also needs to be recommended that whenever they come to be Expecting through therapy or intend to grow to be Expecting they need to communicate with their doctor regarding the desirability of discontinuing the drug fifteen.